You Will Have a New Life

What will you do with your life?

31 years ago, Donald Trump said in an interview: "I'll be 36 next year and I've done everything I can do. Sometimes I think it was a mistake to have raced through it all so fast. What's the next level up? The grass isn't always greener . . . I work, and I don't worry. How can you top that? . . . I protect myself as well as anybody can. I prepare for things but ultimately we all end up going . ....

Squamous carcinoma arising in a branchial cleft cyst: have you ever treated one? Will you?

The existence of primary branchiogenic carcinoma - that is, carcinoma arising in a pre-existing branchial cleft cyst (a benign developmental cyst) - has in recent decades been the subject of increasing scepticism. Recognition of the propensity of a variety of head and neck sites - including in particular the tonsil - to give rise to cervical metastases while the primary tumours themselves remai...

Are you sure you have a strategy?

Executive Overview After more than 30 years of hard thinking about strategy, consultants and scholars have provided an abundance of frameworks for analyzing strategic situations. Missing, however, has been any guidance as to what the product of these tools should be—or what actually constitutes a strategy. Strategy has become a catchall term used to mean whatever one wants it to mean. Executive...

What Will You Sacrifice?

Have you seen? Synapse reorganization—a new partnership revealed

Changes in synaptic function require both qualitative and quantitative reorganization of the synaptic components. Ca plays a central role in this process, but the mechanism has not been fully elucidated. Zhang et al report a novel mechanism whereby Ca/calmodulin (CaM) regulates the stability of the postsynaptic scaffold. Ca/CaM interacts with PSD-95, a core protein in the postsynaptic density (...